Famous as the location of that clever canal, Panama is a fascinating destination on its own. See the luxurious side of the country with a stay at El Otro Lado, located waterside in the tropical forest of Portobelo. A member of Design Hotels, the small property is big on comfort: five bay view villas (one, two and three bedrooms) form a private retreat within a gorgeous UNESCO World Heritage site setting. What to do? Partake in an arts class and learn about painting and wood sculpting, hike in the rain forest, go bird watching, take off on a river or mangrove expedition, or stay close and enjoy paddle boarding, water skiing, inshore fishing and diving, or just wind down with a picnic on the beach.

The property works with the Portobelo Bay Foundation, a local rhythm school, and the Congo Arts Centre and Carpentry Workshop to create authentic guest experiences. There are plenty of options to simply relax, including indulgent spa services. Rates (per accommodation for two guests per night) through Nov. 30 begin at $490 for the Forest & Sea House and the Casa Grande. Higher rates apply to the Sun House and Spirit House. All rates include boat transfers to and from Portobelo and El Otro Lado, breakfast in the Gazebo Restaurant, plus complimentary WiFi.